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It is tempting to speculate that this hexapeptide repeat region is implicated in the anti apoptotic function of BAG 1, since BAG 1 p50 and p46 with the complete hexapeptide repeat has strong anti apoptotic function. BAG 1 p33 with the incomplete hexapeptide repeat is anti apoptotic only in response to cisplatin and staurosporine, but not to paclitaxel and doxorubicine, while BAG 1 p29 lacking the hexapeptide repeat does not have the ability to inhibit apoptosis. The presence of the hexapeptide repeat may also contribute to the suppression of the caspase 3 activation in the C33A cells transfected with the native full length BAG 1, BAG 1 p50 and p46 in the apoptosis signal transduction pathway.

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